¿Qué es la enfermedad de Alzheimer?




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1: Egnaczyk GF, Greis KD, Stimson ER, Maggio JE.Photoaffinity cross-linking of Alzheimer's disease amyloid fibrils reveals
interstrand contact regions between assembled beta-amyloid peptide subunits.
Biochemistry. 2001 Oct 2;40(39):11706-14.
PMID: 11570871 [PubMed - indexed for MEDLINE]


2: Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, ForsellC, Stenh C, Luthman J, Teplow DB, Younkin SG, Naslund J, Lannfelt L.
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta
protofibril formation.
Nat Neurosci. 2001 Sep;4(9):887-93.
PMID: 11528419 [PubMed - indexed for MEDLINE]


3: Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL.Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein
transgenic mice: implications for the pathogenesis and treatment of Alzheimer's
disease.
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10273-8.
PMID: 11517335 [PubMed - indexed for MEDLINE]


4: Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S,Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM, Nishimoto I.
c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds
Alzheimer's amyloid precursor protein with JNK.
J Neurosci. 2001 Sep 1;21(17):6597-607.
PMID: 11517249 [PubMed - indexed for MEDLINE]


5: Kallijarvi J, Haltia M, Baumann MH.Amphoterin includes a sequence motif which is homologous to the Alzheimer's
beta-amyloid peptide (Abeta), forms amyloid fibrils in vitro, and binds avidly
to Abeta.
Biochemistry. 2001 Aug 28;40(34):10032-7.
PMID: 11513581 [PubMed - indexed for MEDLINE]


6: Kapaki E, Kilidireas K, Paraskevas GP, Michalopoulou M, Patsouris E.Highly increased CSF tau protein and decreased beta-amyloid (1-42) in sporadic
CJD: a discrimination from Alzheimer's disease?
J Neurol Neurosurg Psychiatry. 2001 Sep;71(3):401-3.
PMID: 11511720 [PubMed - indexed for MEDLINE]


7: Olson JM, Goddard KA, Dudek DM.The amyloid precursor protein locus and very-late-onset Alzheimer disease.
Am J Hum Genet. 2001 Oct;69(4):895-9.
PMID: 11500807 [PubMed - indexed for MEDLINE]


8: Kametani F, Tanaka K, Usami M, Maruyama K, Mori H.Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the
processing of Alzheimer's amyloid precursor protein in PC12D cells.
J Neurol Sci. 2001 Jul 15;188(1-2):27-31.
PMID: 11489281 [PubMed - indexed for MEDLINE]

9: Mann DM, Takeuchi A, Sato S, Cairns NJ, Lantos PL, Rossor MN, Haltia M,Kalimo H, Iwatsubo T.
Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene
show an unusual but characteristic beta-amyloid pathology known as 'cotton wool'
plaques.
Neuropathol Appl Neurobiol. 2001 Jun;27(3):189-96.
PMID: 11489138 [PubMed - indexed for MEDLINE]


10: Mori T, Paris D, Town T, Rojiani AM, Sparks DL, Delledonne A, Crawford F,Abdullah LI, Humphrey JA, Dickson DW, Mullan MJ.
Cholesterol accumulates in senile plaques of Alzheimer disease patients and in
transgenic APP(SW) mice.
J Neuropathol Exp Neurol. 2001 Aug;60(8):778-85.
PMID: 11487052 [PubMed - indexed for MEDLINE]


11: Dickson TC, Vickers JC.The morphological phenotype of beta-amyloid plaques and associated neuritic
changes in Alzheimer's disease.
Neuroscience. 2001;105(1):99-107.
PMID: 11483304 [PubMed - indexed for MEDLINE]


12: Yan R, Han P, Miao H, Greengard P, Xu H.The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines
its late Golgi localization and access to beta -amyloid precursor protein (APP)
substrate.
J Biol Chem. 2001 Sep 28;276(39):36788-96.
PMID: 11466313 [PubMed - indexed for MEDLINE]


13: Massi F, Straub JE.Probing the origins of increased activity of the E22Q "Dutch" mutant Alzheimer's
beta-amyloid peptide.
Biophys J. 2001 Aug;81(2):697-709.
PMID: 11463618 [PubMed - indexed for MEDLINE]


14: Bamberger ME, Landreth GE.Microglial interaction with beta-amyloid: implications for the pathogenesis of
Alzheimer's disease.
Microsc Res Tech. 2001 Jul 15;54(2):59-70. Review.
PMID: 11455613 [PubMed - indexed for MEDLINE]


15: Yamaguchi H, Sugihara S, Ogawa A, Oshima N, Ihara Y.Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes
neurofibrillary pathology in the frontal association cortex of nondemented
senior subjects.
J Neuropathol Exp Neurol. 2001 Jul;60(7):731-9.
PMID: 11444802 [PubMed - indexed for MEDLINE]


16: Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, Beher D, Bayer TA,Beyreuther K, Multhaup G.
Homodimerization of amyloid precursor protein and its implication in the
amyloidogenic pathway of Alzheimer's disease.

J Biol Chem. 2001 Sep 7;276(36):33923-9. PMID: 11438549 [PubMed - indexed for MEDLINE]

  1. 17: Schonknecht P, Pantel J, Klinga K, Jensen M, Hartmann T, Salbach B, Schroder

  2. J.
    Reduced cerebrospinal fluid estradiol levels are associated with increased
    beta-amyloid levels in female patients with Alzheimer's disease.
    Neurosci Lett. 2001 Jul 13;307(2):122-4.
    PMID: 11427315 [PubMed - indexed for MEDLINE]




18: Sabo SL, Ikin AF, Buxbaum JD, Greengard P.The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein,
regulate cell movement.
J Cell Biol. 2001 Jun 25;153(7):1403-14.
PMID: 11425871 [PubMed - indexed for MEDLINE]


19: Terai K, Iwai A, Kawabata S, Tasaki Y, Watanabe T, Miyata K, Yamaguchi T.beta-amyloid deposits in transgenic mice expressing human beta-amyloid precursor
protein have the same characteristics as those in Alzheimer's disease.
Neuroscience. 2001;104(2):299-310.
PMID: 11377835 [PubMed - indexed for MEDLINE]


20: Turnbull S, Tabner BJ, El-Agnaf OM, Twyman LJ, Allsop D.New evidence that the Alzheimer beta-amyloid peptide does not spontaneously form
free radicals: an ESR study using a series of spin-traps.
Free Radic Biol Med. 2001 May 15;30(10):1154-62.
PMID: 11369506 [PubMed - indexed for MEDLINE]


21: Sjogren M, Davidsson P, Gottfries J, Vanderstichele H, Edman A, VanmechelenE, Wallin A, Blennow K.
The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble
amyloid precursor protein correlate in Alzheimer's disease, reflecting a common
pathophysiological process.
Dement Geriatr Cogn Disord. 2001 Jul-Aug;12(4):257-64.
PMID: 11351137 [PubMed - indexed for MEDLINE]


22: Davidsson P, Bogdanovic N, Lannfelt L, Blennow K.Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in
cortical brain regions in Alzheimer's disease.
Dement Geriatr Cogn Disord. 2001 Jul-Aug;12(4):243-50.
PMID: 11351135 [PubMed - indexed for MEDLINE]


23: Terai K, Iwai A, Kawabata S, Sasamata M, Miyata K, Yamaguchi T.Apolipoprotein E deposition and astrogliosis are associated with maturation of
beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the
pathogenesis of Alzheimer's disease.
Brain Res. 2001 May 4;900(1):48-56.
PMID: 11325345 [PubMed - indexed for MEDLINE]


24: Shukla C, Bridges LR.

Tau, beta-amyloid and beta-amyloid precursor protein distribution in the
entorhinal-hippocampal alvear and perforant pathways in the Alzheimer's brain.
Neurosci Lett. 2001 May 11;303(3):193-7.
PMID: 11323118 [PubMed - indexed for MEDLINE]


25: Chong YH, Sung JH, Shin SA, Chung JH, Suh YH.Effects of the beta-amyloid and carboxyl-terminal fragment of Alzheimer's
amyloid precursor protein on the production of the tumor necrosis factor-alpha
and matrix metalloproteinase-9 by human monocytic THP-1.
J Biol Chem. 2001 Jun 29;276(26):23511-7.
PMID: 11306564 [PubMed - indexed for MEDLINE]


26: Iwata H, Tomita T, Maruyama K, Iwatsubo T.Subcellular compartment and molecular subdomain of beta-amyloid precursor
protein relevant to the Abeta 42-promoting effects of Alzheimer mutant
presenilin 2.
J Biol Chem. 2001 Jun 15;276(24):21678-85.
PMID: 11283011 [PubMed - indexed for MEDLINE]


27: Jhee S, Shiovitz T, Crawford AW, Cutler NR.Beta-amyloid therapies in Alzheimer's disease.
Expert Opin Investig Drugs. 2001 Apr;10(4):593-605. Review.
PMID: 11281811 [PubMed - indexed for MEDLINE]


  1. 28: Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, Barbour R, McConlogue

  2. L.
    Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic
    reticulum prevents formation of amyloid beta-peptide.
    J Biol Chem. 2001 Jun 8;276(23):20267-79.
    PMID: 11278337 [PubMed - indexed for MEDLINE]




29: Lahiri DK, Farlow MR, Hintz N, Utsuki T, Greig NH.Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid
beta-peptides in Alzheimer's disease.
Acta Neurol Scand Suppl. 2000;176:60-7.
PMID: 11273593 [PubMed - indexed for MEDLINE]


30: Warrington EK, Agnew SK, Kennedy AM, Rossor MN.Neuropsychological profiles of familial Alzheimer's disease associated with
mutations in the presenilin 1 and amyloid precursor protein genes.
J Neurol. 2001 Jan;248(1):45-50.
PMID: 11266019 [PubMed - indexed for MEDLINE]


31: Dumery L, Bourdel F, Soussan Y, Fialkowsky A, Viale S, Nicolas P,Reboud-Ravaux M.
beta-Amyloid protein aggregation: its implication in the physiopathology of
Alzheimer's disease.
Pathol Biol (Paris). 2001 Feb;49(1):72-85. Review.
PMID: 11265227 [PubMed - indexed for MEDLINE]

32: Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B, DottiCG.
Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced
in Alzheimer's disease brains.
EMBO Rep. 2000 Dec;1(6):530-5.
PMID: 11263499 [PubMed - indexed for MEDLINE]


33: Borroni B, Colciaghi F, Pastorino L, Pettenati C, Cottini E, Rozzini L,Monastero R, Lenzi GL, Cattabeni F, Di Luca M, Padovani A.
Amyloid precursor protein in platelets of patients with Alzheimer disease:
effect of acetylcholinesterase inhibitor treatment.
Arch Neurol. 2001 Mar;58(3):442-6.
PMID: 11255448 [PubMed - indexed for MEDLINE]


34: Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T,Kita Y, Terashita K, Kouyama K, Nishimoto I.
Insulin-like growth factor I (IGF-I) protects cells from apoptosis by
Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an
IGF-binding protein-sensitive manner.
J Neurosci. 2001 Mar 15;21(6):1902-10.
PMID: 11245675 [PubMed - indexed for MEDLINE]


35: Hersberger M, Santiago-Garcia J, Patarroyo-White S, Yan J, Xu X.A dinucleotide deletion in amyloid precursor protein (APP) mRNA associated with
sporadic Alzheimer's disease results in efficient secretion of truncated APP
isoforms from neuroblastoma cell cultures.
J Neurochem. 2001 Mar;76(5):1308-14.
PMID: 11238715 [PubMed - indexed for MEDLINE]


36: Kraszpulski M, Soininen H, Helisalmi S, Alafuzoff I.The load and distribution of beta-amyloid in brain tissue of patients with
Alzheimer's disease.
Acta Neurol Scand. 2001 Feb;103(2):88-92.
PMID: 11227137 [PubMed - indexed for MEDLINE]


37: Ferrer I, Blanco R, Carmona M, Puig B, Ribera R, Rey MJ, Ribalta T.Prion protein expression in senile plaques in Alzheimer's disease.
Acta Neuropathol (Berl). 2001 Jan;101(1):49-56.
PMID: 11194941 [PubMed - indexed for MEDLINE]


38: Russo C, Salis S, Dolcini V, Venezia V, Song XH, Teller JK, Schettini G.Amino-terminal modification and tyrosine phosphorylation of [corrected]
carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's
disease and Down's syndrome brain.
Neurobiol Dis. 2001 Feb;8(1):173-80.
PMID: 11162251 [PubMed - indexed for MEDLINE]


39: Armstrong RA, Lantos PL, Cairns NJ.The spatial patterns of prion protein deposits in Creutzfeldt-Jakob disease:
comparison with beta-amyloid deposits in Alzheimer's disease.
Neurosci Lett. 2001 Jan 26;298(1):53-6.
PMID: 11154834 [PubMed - indexed for MEDLINE]

40: Hoffmann J, Twiesselmann C, Kummer MP, Romagnoli P, Herzog V.A possible role for the Alzheimer amyloid precursor protein in the regulation of
epidermal basal cell proliferation.
Eur J Cell Biol. 2000 Dec;79(12):905-14.
PMID: 11152291 [PubMed - indexed for MEDLINE]


  1. 41: Bayer TA, Wirths O, Majtenyi K, Hartmann T, Multhaup G, Beyreuther K, Czech

  2. C.
    Key factors in Alzheimer's disease: beta-amyloid precursor protein processing,
    metabolism and intraneuronal transport.
    Brain Pathol. 2001 Jan;11(1):1-11. Review.
    PMID: 11145195 [PubMed - indexed for MEDLINE]




42: Takahashi M, Dore S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR,Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH.
Amyloid precursor proteins inhibit heme oxygenase activity and augment
neurotoxicity in Alzheimer's disease.
Neuron. 2000 Nov;28(2):461-73.
PMID: 11144356 [PubMed - indexed for MEDLINE]


43: Hedin HL, Eriksson S, Fowler CJ.Human platelet calcium mobilisation in response to beta-amyloid (25-35): buffer
dependency and unchanged response in Alzheimer's disease.
Neurochem Int. 2001 Feb;38(2):145-51.
PMID: 11137883 [PubMed - indexed for MEDLINE]


44: Kawahara M, Kuroda Y.Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid
protein: channel formation and disruption of calcium homeostasis.
Brain Res Bull. 2000 Nov 1;53(4):389-97. Review.
PMID: 11136994 [PubMed - indexed for MEDLINE]


45: Yasojima K, Akiyama H, McGeer EG, McGeer PL.Reduced neprilysin in high plaque areas of Alzheimer brain: a possible
relationship to deficient degradation of beta-amyloid peptide.
Neurosci Lett. 2001 Jan 12;297(2):97-100.
PMID: 11121879 [PubMed - indexed for MEDLINE]


46: Neve RL, McPhie DL, Chen Y.Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).
Brain Res. 2000 Dec 15;886(1-2):54-66. Review.
PMID: 11119687 [PubMed - indexed for MEDLINE]


47: Chang P, Su Y.Protocol for quantitative and qualitative analyses of the in vitro aggregation
of synthetic beta-amyloid. A method applicable to the identification of
substances that may have therapeutic efficacy for Alzheimer's disease.
Brain Res Brain Res Protoc. 2000 Nov;6(1-2):6-12.
PMID: 11086258 [PubMed - indexed for MEDLINE]

48: Balbach JJ, Ishii Y, Antzutkin ON, Leapman RD, Rizzo NW, Dyda F, Reed J,Tycko R.
Amyloid fibril formation by A beta 16-22, a seven-residue fragment of the
Alzheimer's beta-amyloid peptide, and structural characterization by solid state
NMR.
Biochemistry. 2000 Nov 14;39(45):13748-59.
PMID: 11076514 [PubMed - indexed for MEDLINE]


49: Antzutkin ON, Balbach JJ, Leapman RD, Rizzo NW, Reed J, Tycko R.Multiple quantum solid-state NMR indicates a parallel, not antiparallel,
organization of beta-sheets in Alzheimer's beta-amyloid fibrils.
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13045-50.
PMID: 11069287 [PubMed - indexed for MEDLINE]


50: Dewachter I, van Dorpe J, Spittaels K, Tesseur I, Van Den Haute C, MoecharsD, Van Leuven F.
Modeling Alzheimer's disease in transgenic mice: effect of age and of
presenilin1 on amyloid biochemistry and pathology in APP/London mice.
Exp Gerontol. 2000 Sep;35(6-7):831-41. Review.
PMID: 11053674 [PubMed - indexed for MEDLINE]


51: Mori H.Untangling Alzheimer's disease from fibrous lesions of neurofibrillary tangles
and senile plaques.
Neuropathology. 2000 Sep;20 Suppl:S55-60. Review.
PMID: 11037189 [PubMed - indexed for MEDLINE]


52: Di Luca M, Colciaghi F, Pastorino L, Borroni B, Padovani A, Cattabeni F.Platelets as a peripheral district where to study pathogenetic mechanisms of
alzheimer disease: the case of amyloid precursor protein.
Eur J Pharmacol. 2000 Sep 29;405(1-3):277-83. Review.
PMID: 11033334 [PubMed - indexed for MEDLINE]


53: Frenkel D, Katz O, Solomon B.Immunization against Alzheimer's beta -amyloid plaques via EFRH phage
administration.
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11455-9.
PMID: 11027345 [PubMed - indexed for MEDLINE]


54: Tapiola T, Pirttila T, Mehta PD, Alafuzofff I, Lehtovirta M, Soininen H.Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in
patients with probable and definite Alzheimer's disease.
Neurobiol Aging. 2000 Sep-Oct;21(5):735-40.
PMID: 11016543 [PubMed - indexed for MEDLINE]


55: Tandon A, Rogaeva E, Mullan M, St George-Hyslop PH.Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the
presenilins.
Curr Opin Neurol. 2000 Aug;13(4):377-84. Review.
PMID: 10970053 [PubMed - indexed for MEDLINE]

56: Gandy S, Petanceska S.Neurohormonal signalling pathways and the regulation of Alzheimer beta-amyloid
metabolism.
Novartis Found Symp. 2000;230:239-51; discussion 251-3. Review.
PMID: 10965512 [PubMed - indexed for MEDLINE]


57: Solans A, Estivill X, de La Luna S.A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's
amyloid precursor protein beta-secretase.
Cytogenet Cell Genet. 2000;89(3-4):177-84.
PMID: 10965118 [PubMed - indexed for MEDLINE]


58: Huang TH, Yang DS, Fraser PE, Chakrabartty A.Alternate aggregation pathways of the Alzheimer beta-amyloid peptide. An in
vitro model of preamyloid.
J Biol Chem. 2000 Nov 17;275(46):36436-40.
PMID: 10961999 [PubMed - indexed for MEDLINE]


59: Esler WP, Felix AM, Stimson ER, Lachenmann MJ, Ghilardi JR, Lu YA, VintersHV, Mantyh PW, Lee JP, Maggio JE.
Activation barriers to structural transition determine deposition rates of
Alzheimer's disease a beta amyloid.
J Struct Biol. 2000 Jun;130(2-3):174-83.
PMID: 10940224 [PubMed - indexed for MEDLINE]


60: Khan SM, Cassarino DS, Abramova NN, Keeney PM, Borland MK, Trimmer PA, KrebsCT, Bennett JC, Parks JK, Swerdlow RH, Parker WD Jr, Bennett JP Jr.
Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell
death pathways.
Ann Neurol. 2000 Aug;48(2):148-55.
PMID: 10939564 [PubMed - indexed for MEDLINE]


61: Hashimoto Y, Niikura T, Ito Y, Nishimoto I.Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's
disease mutations of amyloid precursor protein.
J Biol Chem. 2000 Nov 3;275(44):34541-51.
PMID: 10934205 [PubMed - indexed for MEDLINE]


62: Mukaetova-Ladinska EB, Garcia-Siera F, Hurt J, Gertz HJ, Xuereb JH, Hills R,Brayne C, Huppert FA, Paykel ES, McGee M, Jakes R, Honer WG, Harrington CR,
Wischik CM.
Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals
biphasic synaptic protein response during progression of Alzheimer's disease.
Am J Pathol. 2000 Aug;157(2):623-36.
PMID: 10934165 [PubMed - indexed for MEDLINE]


63: Kim HS, Park CH, Cha SH, Lee JH, Lee S, Kim Y, Rah JC, Jeong SJ, Suh YH.Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis
and renders neuronal cells vulnerable to excitotoxicity.
FASEB J. 2000 Aug;14(11):1508-17.

PMID: 10928985 [PubMed - indexed for MEDLINE]

64: Haars R, Schneider A, Bode M, Schubert W.Secretion and differential localization of the proteolytic cleavage products
Abeta40 and Abeta42 of the Alzheimer amyloid precursor protein in human fetal
myogenic cells.
Eur J Cell Biol. 2000 Jun;79(6):400-6.
PMID: 10928455 [PubMed - indexed for MEDLINE]


65: Engel PA, Grunnet M.Atypical dementia and spastic paraplegia in a patient with primary lateral
sclerosis and numerous necortical beta amyloid plaques: new disorder or
Alzheimer's disease variant?
J Geriatr Psychiatry Neurol. 2000 Summer;13(2):60-4.
PMID: 10912726 [PubMed - indexed for MEDLINE]


66: Gandy S, Petanceska S.Regulation of Alzheimer beta-amyloid precursor trafficking and metabolism.
Biochim Biophys Acta. 2000 Jul 26;1502(1):44-52. Review.
PMID: 10899430 [PubMed - indexed for MEDLINE]


67: El-Agnaf OM, Mahil DS, Patel BP, Austen BM.Oligomerization and toxicity of beta-amyloid-42 implicated in Alzheimer's
disease.
Biochem Biophys Res Commun. 2000 Jul 14;273(3):1003-7.
PMID: 10891362 [PubMed - indexed for MEDLINE]


68: Sauder JM, Arthur JW, Dunbrack RL Jr.Modeling of substrate specificity of the Alzheimer's disease amyloid precursor
protein beta-secretase.
J Mol Biol. 2000 Jul 7;300(2):241-8.
PMID: 10873463 [PubMed - indexed for MEDLINE]


69: Murrell JR, Hake AM, Quaid KA, Farlow MR, Ghetti B.Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid
precursor protein gene.
Arch Neurol. 2000 Jun;57(6):885-7.
PMID: 10867787 [PubMed - indexed for MEDLINE]


70: Armstrong RA, Cairns NJ, Lantos PL.Beta-amyloid deposition in the temporal lobe of patients with dementia with Lewy
bodies: comparison with non-demented cases and Alzheimer's disease.
Dement Geriatr Cogn Disord. 2000 Jul-Aug;11(4):187-92.
PMID: 10867443 [PubMed - indexed for MEDLINE]


71: Eckert GP, Cairns NJ, Maras A, Gattaz WF, Muller WE.Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides
in the hippocampus: specific changes in Alzheimer's disease.
Dement Geriatr Cogn Disord. 2000 Jul-Aug;11(4):181-6.
PMID: 10867442 [PubMed - indexed for MEDLINE]

72: Sian AK, Frears ER, El-Agnaf OM, Patel BP, Manca MF, Siligardi G, Hussain R,Austen BM.
Oligomerization of beta-amyloid of the Alzheimer's and the
Dutch-cerebral-haemorrhage types.
Biochem J. 2000 Jul 1;349(Pt 1):299-308.
PMID: 10861242 [PubMed - indexed for MEDLINE]


73: Lehmann DJ, Nagy Z, Litchfield S, Borja MC, Smith AD.Association of butyrylcholinesterase K variant with cholinesterase-positive
neuritic plaques in the temporal cortex in late-onset Alzheimer's disease.
Hum Genet. 2000 Apr;106(4):447-52.
PMID: 10830913 [PubMed - indexed for MEDLINE]


74: Harkany T, Penke B, Luiten PG.beta-Amyloid excitotoxicity in rat magnocellular nucleus basalis. Effect of
cortical deafferentation on cerebral blood flow regulation and implications for
Alzheimer's disease.
Ann N Y Acad Sci. 2000 Apr;903:374-86. Review.
PMID: 10818528 [PubMed - indexed for MEDLINE]


75: Craft S, Asthana S, Schellenberg G, Baker L, Cherrier M, Boyt AA, MartinsRN, Raskind M, Peskind E, Plymate S.
Insulin effects on glucose metabolism, memory, and plasma amyloid precursor
protein in Alzheimer's disease differ according to apolipoprotein-E genotype.
Ann N Y Acad Sci. 2000 Apr;903:222-8.
PMID: 10818510 [PubMed - indexed for MEDLINE]


76: Mehlhorn G, Hollborn M, Schliebs R.Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques
in transgenic Tg2576 mice with Alzheimer pathology.
Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):423-31.
PMID: 10817926 [PubMed - indexed for MEDLINE]


77: Hyman BT, Strickland D, Rebeck GW.Role of the low-density lipoprotein receptor-related protein in beta-amyloid
metabolism and Alzheimer disease.
Arch Neurol. 2000 May;57(5):646-50. Review.
PMID: 10815129 [PubMed - indexed for MEDLINE]


78: Frenkel D, Solomon B, Benhar I.Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed
single-chain antibody.
J Neuroimmunol. 2000 Jul 1;106(1-2):23-31.
PMID: 10814779 [PubMed - indexed for MEDLINE]


79: Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, Roher AE,Walker LC.
Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer
brain extracts in beta -amyloid precursor protein-transgenic mice.
J Neurosci. 2000 May 15;20(10):3606-11.

PMID: 10804202 [PubMed - indexed for MEDLINE]

80: Huang X, Cuajungco MP, Atwood CS, Moir RD, Tanzi RE, Bush AI.Alzheimer's disease, beta-amyloid protein and zinc.
J Nutr. 2000 May;130(5S Suppl):1488S-92S. Review.
PMID: 10801964 [PubMed - indexed for MEDLINE]


81: Cuajungco MP, Goldstein LE, Nunomura A, Smith MA, Lim JT, Atwood CS, HuangX, Farrag YW, Perry G, Bush AI.
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the
redox-silencing and entombment of abeta by zinc.
J Biol Chem. 2000 Jun 30;275(26):19439-42.
PMID: 10801774 [PubMed - indexed for MEDLINE]


82: Kawahara M, Kuroda Y, Arispe N, Rojas E.Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke
intracellular free calcium elevations by a common mechanism in a hypothalamic
GnRH neuronal cell line.
J Biol Chem. 2000 May 12;275(19):14077-83.
PMID: 10799482 [PubMed - indexed for MEDLINE]


83: Riemenschneider M, Schmolke M, Lautenschlager N, Guder WG, Vanderstichele H,Vanmechelen E, Kurz A.
Cerebrospinal beta-amyloid ((1-42)) in early Alzheimer's disease: association
with apolipoprotein E genotype and cognitive decline.
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