¿Qué es la enfermedad de Alzheimer?






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1: Frackowiak J, Mazur-Kolecka B, Kaczmarski W, Dickson D.Deposition of Alzheimer's vascular amyloid-beta is associated with decreased
expression of brain L-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB).
Brain Res. 2001 Jul 13;907(1-2):44-53.
PMID: 11430884 [PubMed - indexed for MEDLINE]


2: Lippa CF, Schmidt ML, Nee LE, Bird T, Nochlin D, Hulette C, Mori H, Lee VM,Trojanowski JQ.
AMY plaques in familial AD: comparison with sporadic Alzheimer's disease.
Neurology. 2000 Jan 11;54(1):100-4.
PMID: 10636133 [PubMed - indexed for MEDLINE]


3: Schmidt ML, Saido TC, Lee VM, Trojanowski JQ.Spatial relationship of AMY protein deposits and different species of Abeta
peptides in amyloid plaques of the Alzheimer disease brain.
J Neuropathol Exp Neurol. 1999 Dec;58(12):1227-33.
PMID: 10604747 [PubMed - indexed for MEDLINE]


4: Lemere CA, Grenfell TJ, Selkoe DJ.The AMY antigen co-occurs with abeta and follows its deposition in the amyloid
plaques of Alzheimer's disease and down syndrome.
Am J Pathol. 1999 Jul;155(1):29-37.
PMID: 10393833 [PubMed - indexed for MEDLINE]


5: Oppermann UC, Salim S, Tjernberg LO, Terenius L, Jornvall H.Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase
(ERAB): regulation of an SDR enzyme activity with implications for apoptosis in
Alzheimer's disease.
FEBS Lett. 1999 May 28;451(3):238-42.
PMID: 10371197 [PubMed - indexed for MEDLINE]


6: Hansis C, Jahner D, Spiess AN, Boettcher K, Ivell R.The gene for the Alzheimer-associated beta-amyloid-binding protein (ERAB) is
differentially expressed in the testicular Leydig cells of the azoospermic by
w/w(v) mouse.
Eur J Biochem. 1998 Nov 15;258(1):53-60.
PMID: 9851691 [PubMed - indexed for MEDLINE]


7: Guo Q, Fu W, Xie J, Luo H, Sells SF, Geddes JW, Bondada V, Rangnekar VM,Mattson MP.
Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of
Alzheimer disease.
Nat Med. 1998 Aug;4(8):957-62.
PMID: 9701251 [PubMed - indexed for MEDLINE]

1: Lambert JC, Mann D, Goumidi L, Harris J, Amouyel P, Iwatsubo T, Lendon C,Chartier-Harlin MC.
Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition
in Alzheimer's disease.
Lancet. 2001 Feb 24;357(9256):608-9.
PMID: 11558492 [PubMed - indexed for MEDLINE]


2: Yamaguchi H, Sugihara S, Ogawa A, Oshima N, Ihara Y.Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes
neurofibrillary pathology in the frontal association cortex of nondemented
senior subjects.
J Neuropathol Exp Neurol. 2001 Jul;60(7):731-9.
PMID: 11444802 [PubMed - indexed for MEDLINE]


3: Scacchi R, Ruggeri M, Gambina G, Martini MC, Ferrari G, Corbo RM.Plasma alpha1-antichymotrypsin in Alzheimer's disease; relationships with APOE
genotypes.
Neurobiol Aging. 2001 May-Jun;22(3):413-6.
PMID: 11378247 [PubMed - indexed for MEDLINE]


4: Cho HS, Hyman BT, Greenberg SM, Rebeck GW.Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE
in Abeta aggregation.
J Neuropathol Exp Neurol. 2001 Apr;60(4):342-9.
PMID: 11305869 [PubMed - indexed for MEDLINE]


5: Jacquier M, Arango D, Villareal E, Torres O, Serrano ML, Cruts M, Montanes P,Cano C, Rodriguez MN, Serneels S, Van Broeckhoven C.
APOE epsilon4 and Alzheimer's disease: positive association in a Colombian
clinical series and review of the Latin-American studies.
Arq Neuropsiquiatr. 2001 Mar;59(1):11-7. Review.
PMID: 11299424 [PubMed - indexed for MEDLINE]


6: Paradowski B, Szczepaniak M, Dobosz T, Sasiadek M.[Apolipoprotein E(ApoE)and tau protein in Alzheimer type dementia]
Pol Merkuriusz Lek. 2000 Nov;9(53):758-9. Polish.
PMID: 11204323 [PubMed - indexed for MEDLINE]


7: Aerssens J, Raeymaekers P, Lilienfeld S, Geerts H, Konings F, Parys W.APOE genotype: no influence on galantamine treatment efficacy nor on rate of
decline in Alzheimer's disease.
Dement Geriatr Cogn Disord. 2001 Mar-Apr;12(2):69-77.
PMID: 11173877 [PubMed - indexed for MEDLINE]


8: Fallin D, Cohen A, Essioux L, Chumakov I, Blumenfeld M, Cohen D, Schork NJ.Genetic analysis of case/control data using estimated haplotype frequencies:
application to APOE locus variation and Alzheimer's disease.
Genome Res. 2001 Jan;11(1):143-51.
PMID: 11156623 [PubMed - indexed for MEDLINE]

9: Ihara Y, Hayabara T, Sasaki K, Kawada R, Nakashima Y, Kuroda S.Relationship between oxidative stress and apoE phenotype in Alzheimer's disease.
Acta Neurol Scand. 2000 Dec;102(6):346-9.
PMID: 11125747 [PubMed - indexed for MEDLINE]


10: Wang JC, Kwon JM, Shah P, Morris JC, Goate A.Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's
disease.
Neurology. 2000 Dec 12;55(11):1644-9.
PMID: 11113217 [PubMed - indexed for MEDLINE]


11: Halimi G, Duplan L, Bideau C, Iniesta D, Berthezene P, Oddoze C, Verdier JM,Michel B, Berge-Lefranc JL.
Association of APOE promoter but not A2M polymorphisms with risk of developing
Alzheimer's disease.
Neuroreport. 2000 Nov 9;11(16):3599-601.
PMID: 11095526 [PubMed - indexed for MEDLINE]


12: Johnston JM, Nazar-Stewart V, Kelsey SF, Kamboh MI, Ganguli M.Relationships between cerebrovascular events, APOE polymorphism and Alzheimer's
disease in a community sample.
Neuroepidemiology. 2000 Nov-Dec;19(6):320-6.
PMID: 11060506 [PubMed - indexed for MEDLINE]


13: Tapiola T, Pirttila T, Mehta PD, Alafuzofff I, Lehtovirta M, Soininen H.Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in
patients with probable and definite Alzheimer's disease.
Neurobiol Aging. 2000 Sep-Oct;21(5):735-40.
PMID: 11016543 [PubMed - indexed for MEDLINE]


14: Zurutuza L, Verpillat P, Raux G, Hannequin D, Puel M, Belliard S, Michon A,Pothin Y, Camuzat A, Penet C, Martin C, Brice A, Campion D, Clerget-Darpoux F,
Frebourg T.
APOE promoter polymorphisms do not confer independent risk for Alzheimer's
disease in a French population.
Eur J Hum Genet. 2000 Sep;8(9):713-6.
PMID: 10980578 [PubMed - indexed for MEDLINE]


15: Asada T, Motonaga T, Yamagata Z, Uno M, Takahashi K.Associations between retrospectively recalled napping behavior and later
development of Alzheimer's disease: association with APOE genotypes.
Sleep. 2000 Aug 1;23(5):629-34.
PMID: 10947030 [PubMed - indexed for MEDLINE]


16: Deb S, Braganza J, Norton N, Williams H, Kehoe PG, Williams J, Owen MJ.APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults
with Down's syndrome.
Br J Psychiatry. 2000 May;176:468-72.
PMID: 10912224 [PubMed - indexed for MEDLINE]

17: Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA.Endocytic pathway abnormalities precede amyloid beta deposition in sporadic
Alzheimer's disease and Down syndrome: differential effects of APOE genotype and
presenilin mutations.
Am J Pathol. 2000 Jul;157(1):277-86.
PMID: 10880397 [PubMed - indexed for MEDLINE]


18: Martin ER, Lai EH, Gilbert JR, Rogala AR, Afshari AJ, Riley J, Finch KL,Stevens JF, Livak KJ, Slotterbeck BD, Slifer SH, Warren LL, Conneally PM,
Schmechel DE, Purvis I, Pericak-Vance MA, Roses AD, Vance JM.
SNPing away at complex diseases: analysis of single-nucleotide polymorphisms
around APOE in Alzheimer disease.
Am J Hum Genet. 2000 Aug;67(2):383-94.
PMID: 10869235 [PubMed - indexed for MEDLINE]


19: Sawada H, Udaka F, Izumi Y, Nishinaka K, Kawakami H, Nakamura S, Kameyama M.Cerebral white matter lesions are not associated with apoE genotype but with age
and female sex in Alzheimer's disease.
J Neurol Neurosurg Psychiatry. 2000 May;68(5):653-6.
PMID: 10766901 [PubMed - indexed for MEDLINE]


20: Evans RM, Emsley CL, Gao S, Sahota A, Hall KS, Farlow MR, Hendrie H.Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a
population-based study of African Americans.
Neurology. 2000 Jan 11;54(1):240-2.
PMID: 10636159 [PubMed - indexed for MEDLINE]

1: Arango D, Cruts M, Torres O, Backhovens H, Serrano ML, Villareal E, MontanesP, Matallana D, Cano C, Van Broeckhoven C, Jacquier M.
Systematic genetic study of Alzheimer disease in Latin America: mutation
frequencies of the amyloid beta precursor protein and presenilin genes in
Colombia.
Am J Med Genet. 2001 Oct 1;103(2):138-43.
PMID: 11568920 [PubMed - indexed for MEDLINE]


2: Cervantes S, Gonzalez-Duarte R, Marfany G.Homodimerization of presenilin N-terminal fragments is affected by mutations
linked to Alzheimer's disease.
FEBS Lett. 2001 Sep 7;505(1):81-6.
PMID: 11557046 [PubMed - indexed for MEDLINE]


3: Kametani F, Tanaka K, Usami M, Maruyama K, Mori H.Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the
processing of Alzheimer's amyloid precursor protein in PC12D cells.
J Neurol Sci. 2001 Jul 15;188(1-2):27-31.
PMID: 11489281 [PubMed - indexed for MEDLINE]


4: Mann DM, Takeuchi A, Sato S, Cairns NJ, Lantos PL, Rossor MN, Haltia M,Kalimo H, Iwatsubo T.
Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene
show an unusual but characteristic beta-amyloid pathology known as 'cotton wool'
plaques.
Neuropathol Appl Neurobiol. 2001 Jun;27(3):189-96.
PMID: 11489138 [PubMed - indexed for MEDLINE]


5: Janssen JC, Lantos PL, Fox NC, Harvey RJ, Beck J, Dickinson A, Campbell TA,Collinge J, Hanger DP, Cipolotti L, Stevens JM, Rossor MN.
Autopsy-confirmed familial early-onset Alzheimer disease caused by the l153V
presenilin 1 mutation.
Arch Neurol. 2001 Jun;58(6):953-8.
PMID: 11405810 [PubMed - indexed for MEDLINE]


6: Gandy S, Naslund J, Nordstedt C.Alzheimer's disease. Molecular consequences of presenilin-1 mutation.
Nature. 2001 Jun 7;411(6838):654-6.
PMID: 11395757 [PubMed - indexed for MEDLINE]


7: Mann DM, Pickering-Brown SM, Takeuchi A, Iwatsubo T.Amyloid angiopathy and variability in amyloid beta deposition is determined by
mutation position in presenilin-1-linked Alzheimer's disease.
Am J Pathol. 2001 Jun;158(6):2165-75.
PMID: 11395394 [PubMed - indexed for MEDLINE]


8: Lambert JC, Mann DM, Harris JM, Chartier-Harlin MC, Cumming A, Coates J,Lemmon H, StClair D, Iwatsubo T, Lendon C.
The -48 C/T polymorphism in the presenilin 1 promoter is associated with an
increased risk of developing Alzheimer's disease and an increased Abeta load in
brain.

J Med Genet. 2001 Jun;38(6):353-5.
PMID: 11389157 [PubMed - indexed for MEDLINE]


9: Davidsson P, Bogdanovic N, Lannfelt L, Blennow K.Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in
cortical brain regions in Alzheimer's disease.
Dement Geriatr Cogn Disord. 2001 Jul-Aug;12(4):243-50.
PMID: 11351135
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