Resumen: Palabras clave




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. 14-day, high-dose acid suppression, non-bismuth quadruple therapies (hybridvs. concomitant) for Helicobacter pylori infection: a randomised trial . Gastroenterology. 2013; 144 (1 Supl (2013 DDW ABSTRACTS)Digestive Disease Week. Orlando (USA), 18-21 Mayo 2013): 53-53

Autores: Molina-Infante J, Romano M, Fern?dez-Bermejo M, Federico A, Gravina AG, Pozzati L, Garc?- Abadia E, Mart?ez-Alcala C, Miranda A, Vinagre-Rodr?uez G, P?ez-Gallardo B, Gata-Cuadrado M, Hern?dez-Alonso M, Rancel F, Gisbert JP

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Servicio: Aparato Digestivo

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. 5 yearsfollow-up after starting renal replacement therapy . G Ital Nefrol. 2010; 27 (S51): 24-24

Autores: Gallego M.S, Castellano I, Mar? J.P, Mora MT, Novillo R, Su?ez M.A, Garcia-Bernalt V, G?ez-Martino JR

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Servicio: Nefrolog?

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. A Bayesian cost-effectiveness analysis of a telemedicine-based strategy for the management of sleep apnoea: a multicentre randomised controlled trial . Thorax. 2015; 70 (11): 1054-1061

Autores: Isetta V, Negr? MA, Monasterio C, Masa JF, Feu N, ?varez A, Campos-Rodriguez F, Ruiz C, Abad J, V?quez-Polo FJ, Farr?R, Galdeano M, Lloberes P, Embid C, de la Pe? M, Puertas J, Dalmases M, Salord N, Corral J, Jurado B, Le? C, Egea C, Mu?z A, Parra O, Cambrodi R, Martel-Escobar M, Arqu?M, Montserrat JM; SPANISH SLEEP NETWORK

Resumen: BACKGROUND: Compliance with continuous positive airway pressure (CPAP) therapy is essential in patients with obstructive sleep apnoea (OSA), but adequate control is not always possible. This is clinically important because CPAP can reverse the morbidity and mortality associated with OSA. Telemedicine, with support provided via a web platform and video conferences, could represent a cost-effective alternative to standard care management. AIM: To assess the telemedicine impact on treatment compliance, cost-effectiveness and improvement in quality of life (QoL) when compared with traditional face-to-face follow-up. METHODS: A randomised controlled trial was performed to compare a telemedicine-based CPAP follow-up strategy with standard face-to-face management. Consecutive OSA patients requiring CPAP treatment, with sufficient internet skills and who agreed to participate, were enrolled. They were followed-up at 1, 3 and 6Q97;months and answered surveys about sleep, CPAP side effects and lifestyle. We compared CPAP compliance, cost-effectiveness and QoL between the beginning and the end of the study. A Bayesian cost-effectiveness analysis with non-informative priors was performed. RESULTS: We randomised 139 patients. At 6Q97;months, we found similar levels of CPAP compliance, and improved daytime sleepiness, QoL, side effects and degree of satisfaction in both groups. Despite requiring more visits, the telemedicine group was more cost-effective: costs were lower and differences in effectiveness were not relevant. CONCLUSIONS: A telemedicine-based strategy for the follow-up of CPAP treatment in patients with OSA was as effective as standard hospital-based care in terms of CPAP compliance and symptom improvement, with comparable side effects and satisfaction rates. The telemedicine-based strategy had lower total costs due to savings on transport and less lost productivity (indirect costs).

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Servicio: Servicio de Neumolog?

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. A comprehensive, national survey of spirometry in Spain: current bottlenecks and future directions in primary and secondary care . Chest. 2013; 144 (2): 601-609

Autores: L?ez-Campos JL, Soriano JB, Calle M; Encuesta de Espirometr? en Espa? (3E) Project [Riesco Miranda JA, miembro colaborador].

Resumen: BACKGROUND: We aimed to evaluate the availability and practice of spirometry, training of technicians, and spirometer features and maintenance in Spain in both primary care (PC) and secondary care (SC) centers. METHODS: We used a nationwide, cross-sectional, 36-item telephone survey of health-care centers in Spain to target the technician in charge of conducting spirometries in PC and SC centers where outpatient respiratory patients are routinely evaluated. The questions surveyed for resources, training, spirometer use, bronchodilator tests, and spirometer features and maintenance. RESULTS: Of a total of 1,259 centers screened, 605 PC centers (21.2% of the PC centers in Spain) and 200 SC centers (24.9% of the SC centers in Spain) were surveyed. The response rate was 85.4% for PC centers and 75.1% for SC centers. All together, 19% of screened centers did not have a spirometer or were not using it. The number of spirometers per center and spirometries conducted per week was higher in SC centers than in PC centers (P < .001). Most centers received training for conducting spirometries, but this was periodically done in < 40%. Most centers used two inhalations of salbutamol for the bronchodilator test, but the international criteria of a positive test was considered only in 55.8% of PC and 52.8% of SC centers. Calibration of the spirometer was never done in 10.5% of PC and 3.1% of SC centers. CONCLUSIONS: This survey maps for the first time, to our knowledge, the current situation of spirometry in Spain, identifying bottlenecks and suggesting future directions applicable in both PC and SC centers and elsewhere. PMID: 23411500 [PubMed - indexed for MEDLINE]

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Servicio: Neumolog?

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. A controlled trial of noninvasive ventilation for chronic obstructive pulmonary disease exacerbations . J Crit Care. 2009; 24 (3): 473-

Autores: Carrera M, Mar? JM, Ant? A, Chiner E, Alonso ML, Masa JF, Marrades R, Sala E, Carrizo S, Giner J, Gomez-Merino E, Teran J, Disdier C, Agust?AG, Barb?F.

Resumen: PURPOSE: This prospective, multicenter, double-blind, placebo-controlled study tested the hypothesis that noninvasive positive pressure ventilation reduces the need for endotracheal intubation in patients hospitalized in a pulmonary ward because of acute exacerbation of chronic obstructive pulmonary disease. MATERIALS AND METHODS: Seventy-five consecutive patients with exacerbation (pH, 7.31 +/- 0.02; Pao(2), 45 +/- 9 mm Hg; Paco(2), 69 +/- 13 mm Hg) were randomly assigned to receive noninvasive ventilation or sham noninvasive ventilation during the first 3 days of hospitalization on top of standard medical treatment. RESULTS: The need for intubation (according to predefined criteria) was lower in the noninvasive ventilation group (13.5% vs 34%, P < .01); in 31 patients with pH not exceeding 7.30, these percentages were 22% and 77%, respectively (P < .001). Arterial pH and Paco(2) improved in both groups, but changes were enhanced by noninvasive ventilation. Length of stay was lower in the noninvasive ventilation group (10 +/- 5 vs 12 +/- 6 days, P = .06). In-hospital mortality was similar in both groups. CONCLUSIONS: These results demonstrate that noninvasive positive pressure ventilation, in a pulmonary ward, reduces the need for endotracheal intubation, particularly in the more severe patients, and leads to a faster recovery in patients with acute exacerbation of chronic obstructive pulmonary disease

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Servicio: Neumolog?

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. A Delayed hypersensitivity reaction due to Etoricoxib . J Allergy Clin Immunol. 2009; 123 (2 Supl 1): 240-240

Autores: Rodr?uez Trabado A, Garc? N?ez I, Hern?dez Arbeiza F

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Servicio: Alergolog?

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. A disease management program intervention in elderly patients with high comorbidity: Results of a randomized-controlled trial (HF-GERIATRICS) . Eur Geriatr Med. 2013; 4 (Supl 1(9th Congress of the EUGMS, Venice, 2-4 October 2013)): 15-15

Autores: Rodriguez-Pascual C, Paredes-Galan E, Ferrero-Martinez A L, Gonz?ez-Guerrero J L, Hornillos M. Abizanda PF. Suarez R. Menendez-Colino F, Rodr?uez-Artalejo HF-GERIATRICS study group

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Servicio: Geriatr?

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. A new approach to grading and treating COPD based on clinical phenotypes: summary of the Spanish COPD guidelines (GesEPOC . Prim care respir j. 2013; 22 (1): 117-121

Autores: Miravitlles M, Soler-Catalu? JJ, Calle M, Molina J, Almagro P, Quintano JA, Trigueros JA, Pi?ra P, Sim? A, Riesco JA, Ancochea J, Soriano JB

Resumen: After the development of the COPD Strategy of the National Health Service in Spain, all scientific societies, patient organisations, and central and regional governments formed a partnership to enhance care and research in COPD. At the same time, the Spanish Society of Pneumology and Thoracic Surgery (SEPAR) took the initiative to convene the various scientific societies involved in the National COPD Strategy and invited them to participate in the development of the new Spanish guidelines for COPD (Gu? Espa?la de la EPOC; GesEPOC). Probably the more innovative approach of GesEPOC is to base treatment of stable COPD on clinical phenotypes, a term which has become increasingly used in recent years to refer to the different clinical forms of COPD with different prognostic implications. The proposed phenotypes are: (A) infrequent exacerbators with either chronic bronchitis or emphysema; (B) overlap COPD-asthma; (C) frequent exacerbators with emphysema predominant; and (D) frequent exacerbators with chronic bronchitis predominant. The assessment of severity has also been updated with the incorporation of multidimensional indices. The severity of the obstruction, as measured by forced expiratory volume in 1 second, is essential but not sufficient. Multidimensional indices such as the BODE index have shown excellent prognostic value. If the 6-minute walking test is not performed routinely, its substitution by the frequency of exacerbations (BODEx index) provides similar prognostic properties. This proposal aims to achieve a more personalised management of COPD according to the clinical characteristics and multidimensional assessment of severity

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Servicio: Neumolog?

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. A new overgrowth syndrome is due to mutations in RNF125 . Human mutat. 2014; 35 (12): 1436-1441

Autores: Tenorio J, Mansilla A, Valencia M, Mart?ez-Glez V, Romanelli V, Arias P, Castrej? N, Poletta F, Guill?-Navarro E, Gordo G, Mansilla E, Garc?-Santiago F, Gonz?ez-Casado I, Vallesp? E, Palomares M, Mori MA, Santos-Simarro F, Garc?-Mi?ur S, Fern?dez L, Mena R, Benito-Sanz S, del Pozo ? Silla JC, Iba?z K, L?ez-Granados E, Mart?-Trujillo A, Montaner D; SOGRI Consortium, Heath KE, Campos-Barros ? Dopazo J, Nevado J, Monk D, Ruiz-P?ez VL, Lapunzina P y Arroyo I [Collaborators The SOGRI (Spanish OverGrowth Registry Initiative)]

Resumen: Overgrowth syndromes (OGS) are a group of disorders in which all parameters of growth and physical development are above the mean for age and sex. We evaluated a series of 270 families from the Spanish Overgrowth Syndrome Registry with no known OGS. We identified one de novo deletion and three missense mutations in RNF125 in six patients from four families with overgrowth, macrocephaly, intellectual disability, mild hydrocephaly, hypoglycemia, and inflammatory diseases resembling Sj?ren syndrome. RNF125 encodes an E3 ubiquitin ligase and is a novel gene of OGS. Our studies of the RNF125 pathway point to upregulation of RIG-I-IPS1-MDA5 and/or disruption of the PI3K-AKT and interferon signaling pathways as the putative final effectors

Palabras clave: F.I 5,122

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Servicio: Pediatria, Neonatolog?

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