3rd international symposium on ozone applications: abstracts
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| 3rd INTERNATIONAL SYMPOSIUM ON OZONE APPLICATIONS: ABSTRACTS Ozone in Medicine. OZ-P-107: OZONOTERAPIA EN HEMIANOPSIA TEMPORAL IZQUIERDA POR INFARTO CEREBRAL. Juan Carlos Piña (a), Yadira Betancourt (b), Yolanda Mapolón (c), Maritza Palma (c), María Betancourt (b) y Lismay Daposa (c). (a) Hospital Pediátrico Provincial de Camagüey "Dr. Eduardo Agramonte Piña", (b) Hospital Militar Clínico Quirúrgico Docente "Dr.Octavio de la Concepción y de la Pedraja", (c) Centro Provincial de Retinosis Pigmentaria, Cuba. Se realizó un estudio analítico longitudinal retrospectivo en un paciente con una hemianopsia temporal izquierda como secuela de un infarto cerebral previo. El estudio se realizó en el Centro Provincial de Retinosis Pigmentaria de Camagüey desde diciembre de 1997 hasta enero del 2000. Para el diagnóstico de la misma se le realizó fondo de ojo, prueba de refracción, prueba de colores y campo visual. El paciente presentó una agudeza visual de mala percepción luminosa del ojo izquierdo. Se le puso tratamiento de ozonoterapia a razón de 15 sesiones, con una concentración de ozono de 50 mg/L. Se le dio seguimiento al paciente durante tres años, con toma de visión y campo visual de forma periódica. Se logró recuperar la visión en menos de 6 meses y se ha mantenido estable sin repetir nuevo cuadro de infarto cerebral y con la recuperación de la agudeza visual. Se demostró que el ozono es efectivo en el tratamiento en las hemianopsia por infarto cerebral, disminuyendo al máximo las secuelas visuales de este caso. OZ-P-109: OZ-:ALGUNAS CONSIDERACIONES SOBRE EFECTOS Y DOSIFICACIONES DEL OZONO. Lázaro Pérez (a) y C.G. Hoffmann (b). (a) Centro Internacional de Retinosis Pigmentaria, Cuba; (b) Walborg Medical Center, Amsterdam, The Netherlands. Se describen algunos efectos del ozono y su relación con las dosificaciones y aplicaciones empleadas y también los conceptos de geo-concentración reactiva y se muestran las dosificaciones propuestas por alguos especialistas europeos. Se puntualizan las contraindicaciones del ozono. Se observan diferentes métodos terapeúticos basados en el concepto de geo-concentración reactiva y su capacidad de estimular los sistemas biológicos. Las dosis en la ozonoterapia deben ser observados cuidadosamente para lograr el efecto deseado. OZ-P-110: OZONOTERAPIA EN ENFERMEDADES VASCULARES PERIFÉRICAS. EXPERIENCIA DE DOS AÑOS. José I. Fernández, Carmen Piña y Bertha Morales. Instituto Nacional de Angiología y Cirugía Vascular, Cuba. Las bondades de la ozonoterapia para poder controlar sepsis, aspectos hemorreológicos y factores de la microcirculación son conocidos. En nuestra Institución, un servicio de ozonoterapia brinda atención especializada, docente e investigativa, a un promedio de 1250 ingresos por año, 6 382 casos de cuerpo de guardia y 12 900 por consulta externa en igual periodo y se prioriza la atención primaria, con un registro de 2 165 casos en 1999. En los 2 años evaluados, el Departamento de Ozonoterapia asistió a un total de 1282 pacientes, los cuales recibieron 9 790 tratamientos, siendo el método más utilizado la vía rectal. El pie diabético constituyó la patología más atendida, siguiéndole en orden las úlceras de etiología venosa. La ozonoterapia constituye en nuestro centro una de las armas terapéuticas de mayor significación para el tratamiento de pacientes. OZ-P-111: USO DEL OZONO EN AFECCIONES VASCULARES PERIFÉRICAS. Esther L. Torres, Rubén T. Moro, Ivia Jiménez y Yeisy Aguilera. Hospital Provincial Universitario "Celestino Hernández Robau", Villa Clara, Cuba. Las enfermedades vasculares periféricas tienen una alta repercusión en la población que las padece, tanto desde el punto de vista personal como social. Su cronicidad obliga a estos pacientes al contacto permanente con los servicios de salud, siendo sus secuelas graves, pudiendo ir desde ulceras crónicas, deformidades, hasta la pérdida de una pierna. Su tratamiento es muy variado y de gran importancia tanto en su profilaxis, como en las medidas terapéuticas y (o) quirúrgicas. La utilización del ozono como agente terapéutico en estas patologías ha demostrado ser un instrumento útil, económico y necesario dentro de los recursos del angiólogo y del cirujano vascular. Este estudio descriptivo contó con 1153 pacientes, tratados con ozonoterapia en el período de 1 año, por diferentes patologías angiológicas, con el objetivo de analizar la utilización de este gas como agente terapéutico en Angilogía y su utilidad en el tratamiento ambulatorio de dichos pacientes. El método aplicado fue la administración diaria de ozono por vía rectal, (con una concentración entre 40 - 50 mg/L), en un período de 15 sesiones. Se obtuvo como resultados una disminución en el número de amputaciones, una mejor y más rápida cicatrización de las lesiones ulcerosas, así como la curación de la linfangitis. Se evaluó el resultado del tratamiento como satisfactorio en más del 80 % de los pacientes tratados, con una disminución marcada del número de ingresos y del promedio de estadía en estos pacientes. Estos resultados constituyen una evidencia clara de lo positivo que ha resultado la aplicación de esta terapéutica en el campo de la Angiología. OZ-P-112: LA OZONOTERAPIA EN ALGUNAS VIROSIS CUTÁNEAS. Jorge R. Delgado, Rolando Wong, Alejandro Noriega y María de los Angeles Molina. Centro de Investigaciones Medico Quirúrgicas, Cuba. Las afecciones cutáneas de etiología viral se presentan en un gran número de pacientes de la población general y también en nuestro medio se observa con mucha frecuencia. Diferentes autores coinciden en señalar que en muchos de estos pacientes se aprecia una depresión en el sistema inmunitario. Conociendo que el ozono además de la acción virucida tiene efectos inmunomoduladores, se llevó a efecto este estudio, en 84 pacientes que recibieron tratamiento con ozono por diferentes vías. Todos los casos diagnosticados como herpes simple se clasificaron, según la localización de la lesión, en genital, labial, y glútea, utilizándose la vía subcutánea simultáneamente con la aplicación tópica de aceite ozonizado, y para el herpes zoster (20 pacientes) solamente se utilizó la vía intramuscular. Podemos plantear que el ozono es efectivo para tratar estas patologías con resultados satisfactorios sobre todo en el herpes simple recidivante que, administrando el ozono por vía subcutánea, se logra controlar la enfermedad. OZ-P-113: EXPERIENCE IN USING OZONETHERAPY TECHNOLOGIES IN MEDICAL INSTITUTIONS OF RAILWAY HEALTH SERVICE. V. M. Kaznin, S. P. Peretyagin, F. S. Layenko, S. E. Kvasov, V. S. Yandyganov, V. N. Kuleshin, N. A. Mironov, V. N. Grechko and I. A. Kalashnikova. Railway Health Service, Russian Association of Ozonetherapy, Nizhny Novgorod, Russia. For the introduction of ozone therapy technologies into the broad practical health care it is necessary to substantiate and sum up the experience of ozone applications in various medicoprophylactic institutions. In 32 medical institutions of the Railway Health Service ozone therapy has been used since 1994. Now the efficiency of the ozone therapy method is being tested for various subdivisions of medicoprophylactic institutions. The introduction of ozone therapy technologies into medical practice led to reconstruction of medical institutions, formation of new subdivisions which make it possible to perform ozone treatments (ozone therapy department or room) as well as to form health data bank for testing the quality and efficiency of ozone therapy used in different categories of patients. Practical use of methods of ozone therapy makes it necessary to work out normative documentation, to compile professional requirements for ozone therapeutists, as well as to provide medical staff for ozone therapy subdivisions. Every physician using ozone therapy can do so only after appropriate training having qualified for the professional practice of ozone therapy. The utilization of ozone equipments and accessories for medical use should be complied with the requirements of epidemiological service. OZ-P-114: OZONETHERAPY IN COMPLEX SURGICAL TREATMENT OF PATIENTS WITH INFECTED TIBIAL FRACTURES AND SOFT TISSUE DEFECTS. Alex B. Zaitsev. Research Institute of Traumatology and Orthopedics, N.Novgorod, Russia. Open tibial fractures are real surgical challenge because of the risk of infection in bone and devitalized soft tissues. The most severe consequence of open tibial fractures is osteomyelitis, which can usually be prevented by prompt surgical intervention within six hours since injury. Complex surgical treatment includes multiple procedures: debridement of wounds; fasciotomy for compartment syndrome; external fixation and wounds irrigation. In order to prevent infectious complications, especially osteomyelitis, ozone therapy is included in the complex of measures. In such situation intramedullary injection of saline solution with ozone concentration of 1,0-1,5 mg/L in 100-150 mL was used. Between 1997 and 1999, 18 patients with infected tibial fractures (14 patients with soft tissue defects) received complex surgical treatment combined with ozone therapy. The use of this method allowed us to achieve good results. Infectious complications were not found in the sample. In the control group made up of 11 patients, ozone therapy was not carried out, only the conventional treatment was used. In two of them deep wound infection was developed with an osteomyelitis outcome. OZ-P-115: OSSEOUS RESIDUAL TREATMENT IN PATIENTS WITH CHRONIC OSTEOMYELITIS OF LONG TUBULAR BONES USING OZONE. Alex B. Zaitsev Research Institute of Traumatology and Orthopedics, Nizhny Novgorod, Russia. We have treated 63 patients with lchronic osteomyelitis of long tubular bones. The purulent process was located on tibia - in 34 patients, on hip - in 29 patients. Posttraumatic osteomyelitis was diagnosed in 44 patients, haematogenous - in 14, gunshot - in 1, purulent complicated total hip joint arthroplasty - in 4. The surgical strategy consist of sequestra and implants removal, osteonecrosis resection, irrigation and external fixation by Ilizarov device or plaster bandage. Immediately after the patient awakened, suction drainage of residual osseous and soft tissues cavity by saline solution with ozone concentration of 2,0 - 3,0 mg/L was started. On the 2nd–3rd day the perfusate was cleared of blood, on the 7th day fibrin was not seen. By the end of the second week the solution and the perfusate did not differ visually. Average terms of drainage tube removal in control group (39 patients), were 24 days, in the sample - 17 days. Thus, using this procedure, in patients with purulent complications of lower limbs allowed to reduce the time of postoperative wound lavage and complete debridement by putting a suture. Local inflammatory reaction to drainage tube long-term stay in soft tissues was never found. OZ-P-116: OZONE THERAPY AND THE NEUROLOGIC BEHAVIOUR OF A BACKBONE OSTECHONDROSIS. A. Mochalov and S. Kotov. Nizhni Novgorod Medical State Academy. Russia. The aim of this research is to study the ozone therapy efficiency and the neurologic behaviour in patients with backbone ostechondrosis. 107 patients with musculotonic, neurodystrophic and radicular syndromes of backbone osteochondrosis (cervical and lumbar localization) were investigated. The average age of patients was 43,8 years, mean duration of the disease was about 6,5 years. In the treatment of the basic group (81 patients, all men) was used ozone therapy by introduction of ozone-oxygen mixture (OOM) in paravertebral zones and in biologically active points, and also local autohemotherapy (LAHT). Control group included 26 patients (all men) at which introduction of oxygen (as a placebo) was combined with LAHT with not ozonized blood. At the end of the treatment, the patients marked essential improvement of health state expressed in decrease of pain, disappearance of hyperpathic component, time intervals without pain, narrowing of irradiation zone. Simultaneously, the backbones mobility was enlarged, the night dreams was improved. The angle of rise, in Lasseg test, in patients with lumbar ischialgia was enlarged on 31 % and in patients with radiculopathy on 24 %, that exceeded positive shifts with respect to control group (p < 0,05). Dynamic of spatial-functional mutual relations of biokinematic chain "backbone-lower extremities" was shown in substantial growth of movements in cervical and lumbar backbone (according to 37 and 51%). The expressiveness of a radicular syndrome has decreased from 1,63 ± 0,21 to 1,17 ± 0,13 (p < 0,05). Positive metabolic influence of OOM in the dystrophic degeneration centers, the rising of pain receptors sensitivity threshold decrease the morbidity of neurodystrophic sites at palpation. On the radiothermometry data, a decrease in the disorder of the temperature in juxtaspinal points and the equalisation of a "temperature asymmetry sign" was marked. Decrease of the motor potentials amplitude, increase of the nervous conducting velocity, decrease of the H-reflex latent period, revealed on the electromyography and electroneuromyography data, testified an improvement of the blood supply in the segments of the spinal cord and spinal roots during ozone therapy. OZ-P-117: OZONE INFLUENCE ON THE LEVEL OF ENDOTOXICOSIS in GENERAL HYPERTHERMIA CONDITION of ONCOLOGIC PATIENTS. G. Boyarinov; M. Goryachev; Y. Brichin; N. Skachov; N. Smirnova; B. Shubin; M. Chusova; A. Ermolaeva and T. Rumyantseva. Military Medical Institute of the Federal Border Guard Service of Russia, Regional Oncologic Center, Nizhni Novgorod, Russia. At present time the general hyperthermia is more frequently used as a chemotherapy modification for oncologic disease treatment. The sessions consist in intravenous infusion of the chemopreparations at the temperature of 40,5 - 41 0C, general anesthesia and craniocerebral hypothermia. This method is used in unoperable and low sensitive to radiation and chemotherapy patients. 27 patients with cancer in different localisation were divided in two groups: control - 15 patients and with ozone therapy - 12 patients. All patients had II-III stage of endotoxicosis. For detoxication, patients of the investigated group received ozone therapy before the general hyperthermia in the form of intravenous infusion of ozonated physiological solution with an ozone concentration of 3 mg/L. After ozone therapy a significant decrease of endotoxicosis was observed. Besides, the general health state improved. After general hyperthermia, endotoxicosis degree and general health state were determined in both groups. Thus, using the ozone therapy as a method of oxidative detoxication is possible to significantly decrease the degree of endotoxicosis in oncologic patients at a general hyperthermia conduction. OZ-P-118: LIPID PEROXIDATION IN ONCOLOGIC PATIENTS TREATED WITH OZONE THERAPY. T. Scherbatyuk, M. Goryachev; Yu. Samochvalova and E. Polinkina. Medical Academy, Nizhni Novgorod, Russia. In the last years, radiation therapy of malignant tumours, undergoes large changes searching methods of selective radiosensitiveness, in order to increase the therapeutic interval between tumoral and normal tissues. With the purpose of intensifying the action of ionizing radiations, intravenous ozonized saline solution, before radiation, were applied in patients suffering of malignant diseases. 26 female patients with the diagnosis of malignant tumours, stage III and IV (uterus and ovary cancer and hysterocarcinoma) were studied. The treatment for the patients of the first group included the use of a fractionated gamma therapy (radiation dose for operated patients - 40 gp and for not operated - 70 gp). To the second group, 3 sessions of ozone-therapy, before the gamma therapy was applied. Increase of the peroxidation processes and decrease of the antioxidant defense system was found, after the sessions of radiation therapy, in the first group, in comparison with the second group, using ozonized saline solution. |
